The distribution of fitness effects of plasmid pOXA-48 in clinical enterobacteria. Fernandez-Calvet A, Toribio-Celestino L, Valle AA, Sastre-Dominguez J, Valdes-Chiara P, Millan AS, DelaFuente J. (2023). https://doi.org/10.1101/2023.07.11.548518
Fitness Costs of Plasmids: A Limit to Plasmid Transmission. Alvaro San Millan, R. Craig MacLean. (2019). Microbial Transmission. https://doi.org/10.1128/microbiolspec.mtbp-0016-2017
Integrative analysis of fitness and metabolic effects of plasmids in Pseudomonas aeruginosa PAO1. Alvaro San Millan, Macarena Toll-Riera, Qin Qi, Alex Betts, Richard J. Hopkinson, James McCullagh, R. Craig MacLean. (2018). The ISME Journal. https://doi.org/10.1038/s41396-018-0224-8
Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance. Jose Antonio Escudero, R Craig MacLean, Alvaro San Millan. (2018). Journal of Visualized Experiments. https://doi.org/10.3791/57386
Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation. Jeronimo Rodriguez-Beltran, J. Carlos R. Hernandez-Beltran, Javier DelaFuente, Jose A. Escudero, Ayari Fuentes-Hernandez, R. Craig MacLean, Rafael Peña-Miller, Alvaro San Millan. (2018). Nature Ecology & Evolution. https://doi.org/10.1038/s41559-018-0529-z
Cooperation, competition and antibiotic resistance in bacterial colonies. Isabel Frost, William P. J. Smith, Sara Mitri, Alvaro San Millan, Yohan Davit, James M. Osborne, Joe M. Pitt-Francis, R. Craig MacLean, Kevin R. Foster. (2018). The ISME Journal. https://doi.org/10.1038/s41396-018-0090-4
PCR-Based Analysis of ColE1 Plasmids in Clinical Isolates and Metagenomic Samples Reveals Their Importance as Gene Capture Platforms. Manuel Ares-Arroyo, Cristina Bernabe-Balas, Alfonso Santos-Lopez, Maria R. Baquero, Kashi N. Prasad, Dolores Cid, Carmen Martin-Espada, Alvaro San Millan, Bruno Gonzalez-Zorn. (2018). Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2018.00469
Evolution of Plasmid-Mediated Antibiotic Resistance in the Clinical Context. Alvaro San Millan. (2018). Trends in Microbiology. https://doi.org/10.1016/j.tim.2018.06.007
Compensatory evolution facilitates the acquisition of multiple plasmids in bacteria. Alfonso Santos-Lopez, Cristina Bernabe-Balas, Alvaro San Millan, Rafael Ortega-Huedo, Andreas Hoefer, Manuel Ares-Arroyo, Bruno Gonzalez-Zorn. (2017). https://doi.org/10.1101/187070
Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria. Alvaro San Millan, Jose Antonio Escudero, Danna R. Gifford, Didier Mazel, R. Craig MacLean. (2016). Nature Ecology & Evolution. https://doi.org/10.1038/s41559-016-0010
A naturally occurring SNP in plasmid pB1000 produces a reversible increase in antibiotic resistance. Alfonso Santos-Lopez, Cristina Bernabe-Balas, Manuel Ares-Arroyo, Rafael Ortega-Huedo, Andreas Hoefer, Alvaro San Millan, Bruno Gonzalez-Zorn. (2016). Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.01735-16
The Genomic Basis of Evolutionary Innovation in Pseudomonas aeruginosa. (2016). PLoS Genet. https://doi.org/10.1371/journal.pgen.1006005
Microbial Evolution: Towards Resolving the Plasmid Paradox. R. Craig MacLean, Alvaro San Millan. (2015). Current Biology. https://doi.org/10.1016/j.cub.2015.07.006
Evaluating the effect of horizontal transmission on the stability of plasmids under different selection regimes. Rafael Peña-Miller, Rogelio Rodríguez-González, R Craig MacLean, Alvaro San Millan. (2015). Mobile Genetic Elements. https://doi.org/10.1080/2159256x.2015.1045115
Small-Plasmid-Mediated Antibiotic Resistance Is Enhanced by Increases in Plasmid Copy Number and Bacterial Fitness. Alvaro San Millan, Alfonso Santos-Lopez, Rafael Ortega-Huedo, Cristina Bernabe-Balas, Sean P. Kennedy, Bruno Gonzalez-Zorn. (2015). Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00235-15
Interactions between horizontally acquired genes create a fitness cost in Pseudomonas aeruginosa. (2015). Nature communications. https://doi.org/10.1038/ncomms7845
Sequencing of plasmids pAMBL1 and pAMBL2 from Pseudomonas aeruginosa reveals a blaVIM-1 amplification causing high-level carbapenem resistance. (2015). Journal of Antimicrobial Chemotherapy.
Culturable aerobic and facultative bacteria from the gut of the polyphagic dung beetleThorectes lusitanicus. Noemi Hernández, José A. Escudero, Álvaro San Millán, Bruno González-Zorn, Jorge M. Lobo, José R. Verdú, Mónica Suárez. (2014). Insect Science. https://doi.org/10.1111/1744-7917.12094
Positive epistasis between co-infecting plasmids promotes plasmid survival in bacterial populations. (2014). The ISME journal. https://doi.org/10.1038/ismej.2013.182
Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids. (2014). Nature communications.
SatR Is a Repressor of Fluoroquinolone Efflux Pump SatAB. Jose Antonio Escudero, Alvaro San Millan, Natalia Montero, Belen Gutierrez, Cristina Martinez Ovejero, Laura Carrilero, Bruno González-Zorn. (2013). Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00515-13
Molecular Organization of Small Plasmids BearingblaTEM-1and Conferring Resistance to β-Lactams in Haemophilus influenzae. Annette Søndergaard, Alvaro San Millan, Alfonso Santos-Lopez, Signe M. Nielsen, Bruno Gonzalez-Zorn, Niels Nørskov-Lauritsen. (2012). Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00408-12
Fitness Cost and Interference of Arm/Rmt Aminoglycoside Resistance with the RsmF Housekeeping Methyltransferases. Belen Gutierrez, Jose A. Escudero, Alvaro San Millan, Laura Hidalgo, Laura Carrilero, Cristina M. Ovejero, Alfonso Santos-Lopez, Daniel Thomas-Lopez, Bruno Gonzalez-Zorn. (2012). Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.06066-11
Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to $β$-lactams in Haemophilus influenzae. (2012). Antimicrobial agents and chemotherapy.
ArmA Methyltransferase in a Monophasic Salmonella enterica Isolate from Food. Sophie A. Granier, Laura Hidalgo, Alvaro San Millan, Jose Antonio Escudero, Belen Gutierrez, Anne Brisabois, Bruno Gonzalez-Zorn. (2011). Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.00308-11
Plasmid-borne 16S rRNA methylase ArmA in aminoglycoside-resistant Klebsiella pneumoniae in Poland. K. Zacharczuk, K. Piekarska, J. Szych, M. Jagielski, L. Hidalgo, A. San Millan, B. Gutierrez, W. Rastawicki, B. Gonzalez-Zorn, R. Gierczynski. (2011). Journal of Medical Microbiology. https://doi.org/10.1099/jmm.0.024026-0
Fluoroquinolone efflux in Streptococcus suis is mediated by SatAB and not by SmrA. (2011). Antimicrobial agents and chemotherapy.
Haemophilus influenzae Clinical Isolates with Plasmid pB1000 Bearing blaROB-1: Fitness Cost and Interspecies Dissemination. A. San Millan, S. Garcia-Cobos, J. A. Escudero, L. Hidalgo, B. Gutierrez, L. Carrilero, J. Campos, B. Gonzalez-Zorn. (2010). Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.01489-09
Contribution of ROB-1 and PBP3 mutations to the resistance phenotype of a $β$-lactamase-positive amoxicillin/clavulanic acid-resistant Haemophilus influenzae carrying plasmid pB1000 in Italy. (2010). Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dkq392
Novel genetic environment of qnrB2 associated with TEM-1 and SHV-12 on pB1004, an IncHI2 plasmid, in Salmonella Bredeney BB1047 from Spain. Belén Gutierrez, Silvia Herrera-Leon, José Antonio Escudero, Laura Hidalgo, Rubén Gonzalez-Sanz, Margarita Arroyo, Álvaro San Millan, María Aurora Echeita, Bruno Gonzalez-Zorn. (2009). Journal of Antimicrobial Chemotherapy. https://doi.org/10.1093/jac/dkp340
Multiresistance in Pasteurella multocida is mediated by coexistence of small plasmids. (2009). Antimicrobial agents and chemotherapy.
VanB-type Enterococcus faecium clinical isolate successively inducibly resistant to, dependent on, and constitutively resistant to vancomycin. (2009). Antimicrobial agents and chemotherapy.
$β$-Lactam resistance in Haemophilus parasuis is mediated by plasmid pB1000 bearing blaROB-1. (2007). Antimicrobial agents and chemotherapy. https://doi.org/10.1128/aac.00242-07
First characterization of fluoroquinolone resistance in Streptococcus suis. (2007). Antimicrobial agents and chemotherapy.
